A groundbreaking discovery has been made by researchers from the University of Cambridge – a biohybrid device that merges human stem cells with bioelectronics. This device aims to create a more efficient neural interface for individuals who have experienced peripheral nervous system injuries that can result in paralysis or amputation. While current neurotechnologies have their own set of limitations such as difficulties in establishing functional connections with transplanted neurons and interacting with healthy cells due to scar tissue formation, this biohybrid device offers a promising solution to these challenges.
The device design created by the Cambridge researchers is nothing short of remarkable. Induced pluripotent stem cells (iPSCs) are utilized to form myocytes, which are the primary component of skeletal muscles. These myocytes are meticulously arranged in a mesh pattern on microelectrode arrays (MEAs) that are thin enough to be attached to nerve endings. The next step is to place the layer of myocytes between the electrodes and live tissue of the device.
The biohybrid device was put to the test when it was implanted in rats. The cell-covered side of the device was affixed to the severed ulnar and median nerves on the rats’ front paws to examine its effectiveness. This marked the first time iPSCs were introduced to living organisms in this manner. The researchers found that cells from iPSCs survived for four weeks after implantation, and the implanted nerves exhibited normal behavior.
The biodevice is a remarkable combination of living human cells and bio-electronic materials that can interact directly with neurons controlling motor function. The device is biodegradable and prevents scar tissue formation, potentially revolutionizing the way humans interact with technology. The researchers firmly believe that their device can solve the challenge of extracting information from the nerve and restoring limb function.
This discovery has implications that could revolutionize the world of medicine. The researchers are confident that their biohybrid device could aid individuals who have experienced amputated limbs. This is accomplished by regenerating neurons and restoring damage to the nervous system resulting from injury or amputation. Furthermore, the use of laboratory-grown stem cells and the compact size of the device make it simple to scale up and implant through a keyhole, a feat that is impossible with standard neural implants that do not contain stem cells.
In conclusion, while the biodevice necessitates additional research and thorough testing before it is used on humans, it represents a promising development in the field of neural implants. The researchers are committed to optimizing and scaling up the device for additional usage, and they are excited about the technology’s potential to open up new treatment options for patients in need.
Google News | Telegram
